The journal Epilepsia antedated the founding of the International League Against Epilepsia. Its publication was thrice interrupted thus creating four series.

The first series
The first series comprised a volume per year with four quarterly issues each. Five volumes have been published from 1909-1915.

The periodical first appeared under the patronage of W. Bechterew, O. Binswanger, J. Hughlings Jackson, L. Luciani, H. Obersteiner and F. Raymond. A year later F. Déjérine replaced Raymond, and for the fourth volume Hughlings Jackson was replaced by Sir William Gowers. Most of the early numbers of Epilepsia were published by a consortium consisting of Scheltema & Holkema (Amsterdam), Jacob Lund (Copenhagen), Baillière & Fils (Paris), Williams & Norgate (London), G.E. Stechert & Co (New York), J.A. Barth (Leipzig), and Nordiska Bokhandeln (Stockholm).

For all five volumes, which appeared until the first World War put an end to this period, J. Donath from Budapest and L.J.J. Muskens from Amsterdam were respectively Editor-in-Chief (Rédacteur-Gérant) and Secretary of the Editorial Board (Secrétaire de la Rédaction).

The second series
This series had volumes spanning a four year period with one issue per year.

Volume 1 - four issues, 1937-1940, published by Levin & Munksgaard-Enjar Munksgaard-Copenhagen.
Editor-in-Chief: H.I. Schou, Copenhagen;
Co-editors: J. Tylor Fox, Lingfield; William G. Lennox, Boston; L.J.J. Muskens, Amsterdam (after Muskens' death: K.H. Stauder, Munich).

Volume 2 - four issues, 1941-1944, printed in America.
Editor-in-Chief: H.I. Schou, Copenhagen;
Co-editors: J. Tylor Fox, Lingfield; William G. Lennox, Boston; K.H. Stauder, Munich.

Volume 3 - four issues, 1945-1948, printed in America.
Editor-in-Chief: William G. Lennox, Boston;
Co-editors: J. Tylor Fox, Lingfield; H.I. Schou, Copenhagen; B.Ch. Ledeboer, Heemstede; Barnaby Cantlon, Argentina; C. Wesley Watson, USA.

Volume 4 - two issues, 1949-1950, printed in America.
Editor-in-Chief: William G. Lennox, Boston;
Co-editors: J.K. Merlis, Framingham; Barnaby Cantlon, Argentina; N.S. Alcock, London; J. Kloek, Heemstede; A. Rémond, Paris; H.P. Stubbe-Teglbjaerg, Dianalund.

The third series
This series had one volume a year and only one issue per volume. In all there were four volumes.

Volume 1 - 1952; Volume 2 - 1953; Volume 3 - 1954; Volume 4 - 1955, printed in America.
Editor-in-Chief: Jerome K. Merlis, Framingham;
Co-editors: Charles D. Aring, USA; Richard G. Berry, USA; Keasely Welch, USA; Paul I. Yakolev, USA.

The fourth series
This is the present series. In the course of its existence, 1959-1999, however, changes did take place, not only of editors, but also in number of issues per volume and publisher. The volumes appeared annually, the present volume being #40.

Volumes 1 - 18 had four issues per volume, except the first volume which covered the years 1959/1960 and comprised five issues with 611 pages (note on page 232, Volume 1).

Volumes 19 - 35 had six issues per volume.

Volumes 36 -till now have 12 issues per volume.

Volumes 1 - 16 were published by Elsevier Publishing Company, Amsterdam.
Volumes 16 - the 8th issue of 36 by Raven Press, New York.
Volumes 36 issue 9 - 8th issue of 39 by Lippincott-Raven, Philadelphia.
Volumes 39 issue 9 - the present (September 1999) by Lippincott Williams & Wilkins, Philadelphia.
Editor-in-Chief of Volume 1 was Sir Francis Walshe;
Co-editors: Volume 1: Henri Gastaut, Marseille; Gilbert Glaser, New Haven, Conn; A.M. Lorentz de Haas, Heemstede (managing editor).
Managing Editor: Volume 2 - 8: A.M. Lorentz de Haas, Heemstede;
Co-editors: Henri Gastaut, Marseilles; Gilbert Glaser, New Haven, Conn. (the March 1968 issue without Lorentz de Haas).
Managing Editor: Volume 9 from issue 2 onward till the end of Volume 10: O. Magnus, Wassenaar;
Co-editors: Henri Gastaut, Marseilles; Gilbert Glaser, New Haven, Conn.
Managing Editor: Volumes 11 - 17 issue 1: Margaret Lennox-Buchthal, Copenhagen (Volume 16 had 5 issues);
Co-editors: Henri Gastaut, Marseilles; Gilbert Glaser, New Haven, Conn.
Editor-in-Chief: Volume 17 from issue 2 onward - Volume 27 issue 5: Arthur Ward, Seattle.
Editor-in-Chief: Volume 27 from issue 6 onward - Volume 35 issue 3: James Cereghino, Bethesda.
Editor-in-Chief: Volume 35 from issue 4 onward - present: Timothy A. Pedley, New York.